Monday July 09, 2007
Male vs Female blood product transfusion (Plasma and apheresis platelets) !

Interesting study published in July 2007 issue of Critical Care Medicine 1 comparing transfusion from male-only versus female donors.

In this retrospective case-control study, 112 patients who received high plasma volume components (more than 2 units of fresh frozen plasma or apheresis platelets) from male-only donors were identified and compared them with from female donors. - patients matched by severity of illness, postoperative state, and number of transfusions. Baseline characteristics, ALI risk factors, and development of ALI were similar between the two groups.
Results:

• Arterial oxygenation (Pao2/Fio2) worsened after the female (p = .008) but not after male-only donor product transfusion (p = .325).
• Male-only component recipients had more ventilator-free days (median 28 vs. 27, p = .006) and
• a trend toward lower hospital mortality rates (14% vs. 24%, p = .054).
• no significant difference in development of ALI after transfusion.

Study concluded that in critically ill recipients of high plasma volume components, gas exchange worsened significantly after transfusion of female but not male donor components.


Reference: Click to get article/abstract

Transfusion from male-only versus female donors in critically ill recipients of high plasma volume components - Critical Care Medicine. 35(7):1645-1648, July 2007.


Few Previous Related Pearls:

FFP and platelet transfusion may be associated more with ALI/ARDS than pRBC transfusion

Why we call it cryoprecipitate?

How much FFP?