APC at one glance
Activated Protein C (Xigris) entered Critical Care Medicine culture with a big bang but over time its efficiency and safety has been questioned but still it is a valuable tool in intensivists' arsenals. Below is a nice picture showing various actions for APC application.
TF = tissue factor
IL-1 = interleukin 1
IL-6 = interleukin 6
TNF-alpha = tumor necrosis factor alpha
PAR-1 = protease activated receptor 1
EPCR = endothelial protein C receptor
TM = thrombomodulin
Click to get bigger imagesource: Frontiers in Bioscience 11, 2381-2399, September 1, 2006
